The crystalline tris(hydroxymethyl)ainomethane ("Tris") salt of 2-deoxy-2-[(R)-3-hydroxytetradecanamido]-3-0-[(R)-3-hydroxytetradecanoyl]-cY-D-glucopyranose 1 -phosphate (lipid X) has been synthesised from 2-animo-2-deoxy-D-glucose hydrochloride in five steps in -50% overall yield. The key step was
✦ LIBER ✦
Synthesis of O-{2-deoxy-2-[(3R)-3-hydroxytetradecanamido]-β-d-glucopyranosyl 4-phosphate}-(1→6)-2-deoxy-2-[(3R)-3-hydroxytetradecanamido]-d-glucose. The disaccharide route
✍ Scribed by Daniel Charon; Ladislas Szabó
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 205 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0008-6215
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