Synthetic mucin fragments: 3-O-[2-Acetamido-4,6-di-O-acetyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-d-galactopyranosyl)-β-d- glucopyranosyl]-2,4,6-tri-O-acetyl-α-d-galactopyranosyl bromide and p-nitrophenyl 3-O-(2-acetamido-2-deoxy-3-O-β-d-galactopyranosyl-β-d-glucopyranosyl)-β-d-galactopyranoside
✍ Scribed by Katsunori Kohata; Saeed A. Abbas; Khushi L. Matta
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 360 KB
- Volume
- 132
- Category
- Article
- ISSN
- 0008-6215
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📜 SIMILAR VOLUMES
In a continuing program for the synthesis of oligosaccharides that occur as part of mutinous glycoconjugates, we previously described\* the synthesis of the disaccharide methyl 3-0-(2-acetamido-2-deoxy-P-D-glucopyranosyl)-a-D-galactopyranoside (1). We have also demonstrated that 1 could be readily
Condensation of benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-a-D-galactopyranoside with 2,3,4-tri-o-acetyl-a-D-fucopyranosyl bromide in 1: 1 nitromethane-benzene, in the presence of powdered mercuric cyanide, afforded benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-3-0-(2,3,4-tri-O-acetyl-P-D-fucopyran
Halide-assisted glycosyIation, using a non-p~icipating Z-substituent (benzyl) in the glycosyl halide, was used to obtain the ~-D-gaiactosyl linkage and silver triflate promotion with a participating 2-substituent (benzoyl) was used to obtain the /3-D-galactosyl linkage in a facile synthesis of the t
## Note The Koenig+Knorr reaction of benzyl 4,6-O-benzylidene-fl-o-galactopyranoside with 2,3,4,6-tetra-O-acetyl-a-D-galactopyranosyl bromide In continuation of our studiesle5 on the relative reactivity ot' HO-2 and -3 in 4,6-O-benzylidene-D-glucopyranosides towards u-glucosylation 111 reactions o