Hypomethylation of the cyclooxygenase-2 promoter in gastric adenocarcinomas with microsatellite instability
โ Scribed by Mahmood Akhtar; Romina M. Magno; Jing Yin; Albert S. Fleisher; Gen Tamura; Stephen J. Meltzer; Keith T. Wilson
- Book ID
- 119425404
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 303 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0016-5085
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Overexpression of cyclooxygenase-2 (COX-2) has been reported in gastric cancers. However, the relationship between expression of COX-2 and clinico-pathological or genotypic features has not been elucidated. To address the issue, expression of COX-2 protein was analyzed in 100 gastric cancers as well
Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i