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Infrequent hMSH2 mutations in sporadic gastric adenocarcinoma with microsatellite instability

✍ Scribed by Ming-Shiang Wu; Jin-Chuan Sheu; Chia-Tung Shun; Wei-Jei Lee; Jin-Town Wang; Teh-Hong Wang; Ann-Lii Cheng; Jaw-Town Lin

Book ID
117468418
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
766 KB
Volume
112
Category
Article
ISSN
0304-3835

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## BACKGROUND. Widespread microsatellite instability (MSI) occurs in nearly 15% of sporadic colorectal cancers. Large bowel carcinomas with high-frequency MSI (MSI-H) (instability at Υ† 30% of microsatellite loci) are believed to display distinctive pathologic features and to behave less aggressive