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Hypermethylation of the CDKN2/p16INK4A Promotor in Thyroid Carcinogenesis

✍ Scribed by Carsten Boltze; Stephan Zack; Claudia Quednow; Silke Bettge; Albert Roessner; Regine Schneider-Stock

Book ID: 111731713
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 298 KB
Volume: 199
Category: Article
ISSN: 0344-0338
DOI: 10.1078/0344-0338-00436

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There have been few reports on genetic alterations in thymomas. To investigate the expression of p16 INK4A , RB, p53 and cyclin D1 in thymomas, we first examined 36 thymomas (non-invasive type, 16 cases; invasive type, 20 cases) and 3 thymic carcinomas, using immunohistochemistry. Abnormal expressio