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p16 (cdkN2/MTS1/INK4A) expression in sporadic colorectal carcinomas

✍ Scribed by L.M Rodriguez; R.B Penetrante; N.J Nowak; M Rodriguez-Bigas; D.L Driscoll; E Hoover; N.J Petrelli; T.B Shows


Book ID
114123646
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
163 KB
Volume
57
Category
Article
ISSN
0149-7944

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The p16 INK4A /CDKN2/MTS1 gene encodes a specific inhibitor of cyclin-dependent kinases (CDKs) 4 and 6. This study investigates p16 INK4A gene status and expression in mesenchymal tumours, in particular soft tissue sarcomas (STSs). Employing non-radioactive polymerase chain reaction-single strand co