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Hydroxylamine-containing inhibitors of polyamine biosynthesis and impairment of colon cancer cell growth

✍ Scribed by Vladan Milovica; Lyudmila Turchanowa; Alex R. Khomutov; Radii M. Khomutov; Wolfgang F. Caspary; Jürgen Stein

Book ID
113992522
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
245 KB
Volume
61
Category
Article
ISSN
0006-2952

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The cytotoxicity of two novel polyamine analogues was compared with that of a known cytotoxic drug, etoposide, in a human promyelogenous leukemic cell line. CHEN-spm showed significant acute cytotoxicity in these cells and was comparable to etoposide in terms of IC 50 value. The cell death observed