Modulation of murine erythroleukemic cell differentiation by inhibitors of polyamine biosynthesis
✍ Scribed by Eliane Meilhoc; Marie-José Moutin; H. Beverley Osborne
- Book ID
- 102883967
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 754 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0021-9541
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The cytotoxicity of two novel polyamine analogues was compared with that of a known cytotoxic drug, etoposide, in a human promyelogenous leukemic cell line. CHEN-spm showed significant acute cytotoxicity in these cells and was comparable to etoposide in terms of IC 50 value. The cell death observed
## Abstract The inclusion of DMSO in the media of suspension cultures of Friend erythroleukemia cells results in the erythroid differentiation of these cells. The studies reported here were directed towards answering two questions: (1) How long an exposure to DMSO is necessary to induce the differe
The Friend erythroleukemia cell line was used to study the and Riflcind, 1978), it has been shown that numerous agents, binding and bialogical properties of the photosensitizer he-of which the best known is DMSO (Friend et al., 1971), are matoporphyrin derivative (HPD) on a differentiating system. c