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Flavanols and procyanidins of cocoa and chocolate inhibit growth and polyamine biosynthesis of human colonic cancer cells

✍ Scribed by Stéphanie Carnésecchi; Yann Schneider; Sheryl A Lazarus; David Coehlo; Francine Gossé; Francis Raul


Book ID
117467132
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
198 KB
Volume
175
Category
Article
ISSN
0304-3835

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The cytotoxicity of two novel polyamine analogues was compared with that of a known cytotoxic drug, etoposide, in a human promyelogenous leukemic cell line. CHEN-spm showed significant acute cytotoxicity in these cells and was comparable to etoposide in terms of IC 50 value. The cell death observed