New HyTs are a knockout: we previously reported that labeling HaloTag proteins with low molecular weight hydrophobic tags (HyTs) leads to targeted degradation of HaloTag fusion proteins. In this report, we employed a chemical approach to extend this hydrophobic tagging methodology to highly stabiliz
Hydrophobicity and stability for a family of model proteins
β Scribed by Norbert Muller
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1993
- Tongue
- English
- Weight
- 809 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0006-3525
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A fundamental characteristic of soluble globular protein structure is a hydrophobic core and protein exterior comprised predominantly of hydrophilic residues. This distribution of amino acid residue hydrophobicity, from protein interior to exterior, has recently been profiled with the use of hydroph
Cholera is an extremely virulent disease. It has long been, and continues to be, a world health issue. It affects both children and adults and can kill within hours. During the 19th century, cholera spread across the world from its original reservoir in the Ganges delta in India [23]. There have bee