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Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins

✍ Scribed by Dr. Hyun Seop Tae; Dr. Thomas B. Sundberg; Dr. Taavi K. Neklesa; Devin J. Noblin; Dr. Jeffrey L. Gustafson; Dr. Anke G. Roth; Kanak Raina; Prof. Craig M. Crews

Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 461 KB
Volume: 13
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.201100793

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✦ Synopsis

New HyTs are a knockout: we previously reported that labeling HaloTag proteins with low molecular weight hydrophobic tags (HyTs) leads to targeted degradation of HaloTag fusion proteins. In this report, we employed a chemical approach to extend this hydrophobic tagging methodology to highly stabilized proteins by synthesizing and evaluating a library of HyTs, which led to the identification of HyT36.

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