Hydrolysis of lincomycin-2-phosphate and clindamycin-2-phosphate
โ Scribed by T. O. Oesterling; E. L. Rowe
- Book ID
- 102914467
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 550 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The separation of clindamycin 2-phosphate from clindamycin 3-phosphate, clindamycin 4-phosphate, clindamycin B 2-phosphate, and lincomycin 2-phosphate was achieved by liquid chromatography on triethylaminoethyl cellulose using a 254-nm monitor. The compounds have low molar absorptivities a t 254 nm
The aqueous solubilities of lincomycin and clindamycin 2-palmitate esters are compared. Clindamycin 2-palmitate hydrochloride has an unusually high solubility at 25 degrees, which is due to micelle formation. Both compounds are surface active with relatively low critical micelle concentrations. Howe