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Synthesis and bioactivity of lincomycin-2-phosphate

✍ Scribed by W. Morozowich; D. J. Lamb; H. A. Karnes; F. A. MacKellar; C. Lewis; K. F. Stern; E. L. Rowe

Book ID
102913484
Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
564 KB
Volume
58
Category
Article
ISSN
0022-3549

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## Abstract In search for new antibiotics we replaced the amide moiety of lincomycin **1** by a 1,2,3‐triazole ring. The 1,2,3‐triazoles **10a**–**10k** were obtained as single regioisomers by β€˜click reaction’ of azide **5** with the alkyne **9k**, derived from propyl hygric acid, and the alkyl, ar