Liquid chromatography of clindamycin 2-phosphate on triethylaminoethyl cellulose

✍ Scribed by Walter Morozowich; Roger G. Williams

• Book ID: 102405644
• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 341 KB
• Volume: 64
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600640227

✦ Synopsis

The separation of clindamycin 2-phosphate from clindamycin 3-phosphate, clindamycin 4-phosphate, clindamycin B 2-phosphate, and lincomycin 2-phosphate was achieved by liquid chromatography on triethylaminoethyl cellulose using a 254-nm monitor. The compounds have low molar absorptivities a t 254 nm (<17), and UV detection is made possible by the high capacity support triethylaminoethyl cellulose. Linear peak height response versus concentration allows rapid quantitation of clindamycin 2phosphate. Keyphrases 0 Clindamycin 2-phosphate-separation from other clindamycin compounds, triethylaminoethyl cellulose column, liquid chromatography 0 Triethylaminoethyl cellulose-used for liquid chromatographic separation of clindamycin 2-phosphate from other clindamycin compounds 0 Liquid chromatography-separation, clindamycin 2-phosphate from other clindamycin compounds