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Huntington's disease-like 2 in Brazil—Report of 4 patients

✍ Scribed by Guilherme G. Riccioppo Rodrigues; Ruth H. Walker; Alexis Brice; Cécile Cazeneuve; Odile Russaouen; Helio A.G. Teive; Renato Puppi Munhoz; Nilson Becker; Salmo Raskin; Lineu Cesar Werneck; Wilson Marques Junior; Vitor Tumas

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
225 KB
Volume
23
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Huntington's disease‐like 2 (HDL2) is a neurodegenerative disorder found in people of African ancestry with clinical, radiological, and neuropathological manifestations similar to Huntington's disease (HD). HDL2 is caused by a pathological expansion of CAG/CTG triplets in exon 2A of the JPH3 gene. We describe four cases of HDL2 from four unrelated families, and discuss their clinical findings. HDL2 should be considered in every patient with an HD‐like phenotype who tests negative for the HD mutation, even if African ancestry is not immediately apparent. © 2008 Movement Disorder Society

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