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Huntingtin and the molecular pathogenesis of Huntington's disease

✍ Scribed by Landles, Christian; Bates, Gillian P.

Book ID
110032604
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
107 KB
Volume
5
Category
Article
ISSN
1469-221X

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## Abstract Huntington's disease is one of the several neurodegenerative diseases caused by dominant mutations that expand the number of glutamine codons within an existing poly‐glutamine (polyQ) repeat sequence of a gene. An expanded polyQ sequence in the huntingtin gene is known to cause the hunt

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Huntington's disease (HD) is a progressive neurodegenerative disease striking principally medium spiny GABAergic neurons of the caudate nucleus of the basal ganglia. It affects about one in 10,000 individuals and is transmitted in an autosomal dominant fashion. The molecular basis of the disease is