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Huntingtin oligomeric structures and their potential neurotoxic role in Huntington's disease

✍ Scribed by Y. Porat; Z. Hou; C.A. Ross; M. Poirier

Book ID
108216977
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
51 KB
Volume
2
Category
Article
ISSN
1549-9634

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## Abstract The neurotransmitter dopamine is oxidized to its quinone (DA‐Q), which at neutral pH undergoes intramolecular cyclization by 1,4‐Michael addition, followed by oxidation to form leukochrome, then aminochrome, and finally neuromelanin. At lower pH, the amino group of DA is partially proto