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The role of post-translational modifications of huntingtin in the pathogenesis of Huntington’s disease

✍ Scribed by Yan Wang; Fang Lin; Zheng-Hong Qin

Book ID
107639285
Publisher
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Year
2010
Tongue
English
Weight
718 KB
Volume
26
Category
Article
ISSN
1673-7067

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## Abstract Huntington's disease is one of the several neurodegenerative diseases caused by dominant mutations that expand the number of glutamine codons within an existing poly‐glutamine (polyQ) repeat sequence of a gene. An expanded polyQ sequence in the huntingtin gene is known to cause the hunt