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Huntington’s disease: degradation of mutant huntingtin by autophagy

✍ Scribed by Sovan Sarkar; David C. Rubinsztein

Book ID
111312544
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
167 KB
Volume
275
Category
Article
ISSN
1432-1327

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## Abstract Huntington's disease is one of the several neurodegenerative diseases caused by dominant mutations that expand the number of glutamine codons within an existing poly‐glutamine (polyQ) repeat sequence of a gene. An expanded polyQ sequence in the huntingtin gene is known to cause the hunt