Human ovarian carcinoma lysis by cytotoxic t cells targeted by bispecific monoclonal antibodies: Analysis of the antibody components
✍ Scribed by D. Mezzanzanica; S. Canevari; S. Ménard; S. M. Pupa; E. Tagliabue; A. Lanzavecchia; M. I. Colnaghi
- Book ID
- 118283970
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- French
- Weight
- 866 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
T lymphocytes of 8 patients with ovarian cancer were targeted to the tumor cells using F(ab')2 fragments of a bispecific monoclonal antibody (bsAb), specific for CD3 (a component of the T lymphocyte receptor for antigen) and for the folate receptor MOv I 8 (overexpressed by ovarian carcinoma cells)
In the perspective of therapeutic in vivo targeting for T-cell attack, the monoclonal antibody (MAb) MOvI8, selected for i t s restricted reactivity with human ovarian carcinoma, and an anti-T3 MAb were used t o produce heteroconjugate or hybrid antibodies derived by fusion of relevant hybridomas. S