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Re-targeting of human lymphocytes expressing the T-cell receptor gamma/delta to ovarian carcinoma cells by the use of bispecific monoclonal antibodies

✍ Scribed by Silvano Ferrini; Ignazia Prigione; Serafina Mammouti; Maria Ines Colnaghi; Sylvie Ménard; Alessandro Moretta; Lorenzo Moretta

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
636 KB
Volume
44
Category
Article
ISSN
0020-7136

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Retargeting of T-cell-receptor gamma/del
Retargeting of T-cell-receptor gamma/delta+ lymphocytes against tumor cells by bispecific monoclonal antibodies. Induction of cytolytic activity and lymphokine production
✍ Silvano Ferrini; Ignazia Prigione; Serafina Mammoliti; Maria Ines Colnaghi; Sylv 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 307 KB

We have recently selected MAbs specific for different molecular forms of the TCR gammddelta (expressed by distinct cell subsets), able to activate TCR gamma/delta+ cells. Two of these reagents (GI and Al3) were used for the construction of bispecific MAbs in conjunction with a MAb (Mov 19) directed