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Human meningiomas co-express platelet-derived growth factor (pdgf) and pdgf-receptor genes and their protein products

โœ Scribed by Marius Maxwell; Theofanis Galanopoulos; E. Tessa Hedley-Whyte; Peter McL. Black; Harry N. Antoniades

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
841 KB
Volume
46
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

The present studies investigated the expression of the platelet-derived growth factor (PDGF) and PDGF-receptor genes in human meningiomas. Northern blot analysis demonstrated that all meningiomas examined expressed both the c-sidPDGF-2 proto-oncogene and the PDGF-receptor gene. In situ hybridization localized the c-sis mRNA and the PDGFreceptor mRNA in the tumor cells of the meningioma tissues. Control pachymeninges derived from adult individuals, without meningiomas, expressed only PDGF-receptor mRNA but not the c-sis mRNA. Immunocytochemistry studies detected both the c-sis and the PDGF-receptor protein products in meningioma tissues but only the PDGF-receptor protein products in control pachymeninges. These findings indicate the presence of an autocrine mechanism in human meningiomas based on the co-expression of the c-sidPDGF-2 proto-oncogene and PDGF-receptor gene and their protein products. This co-expression of a potent mitogen and its receptor may contribute to the growth and maintenance of human meningiomas.

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