Vascular endothelial growth factor (VEGF) is a potent angiogenic polypeptide that activates 2 distinct high-affinity tyrosine kinase receptors, flk-1/KDR and flt-1. In the present study, we characterized the expression of VEGF and its receptors flk-1/KDR and flt-1 in the normal human pancreas and in
Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer
✍ Scribed by Matthias Ebert; Munehiro Yokoyama; Helmut Friess; Michael S. Kobrin; Markus W. Büchler; Murray Korc
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 986 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Activins and inhibins belong to the transforming growth factor- (TGF-) superfamily of multifunctional cytokines that bind to transmembrane receptors with serine/threonine kinase activity. In this study, we characterized the levels of expression of 3 activin/inhibin subunits (A, B, ␣), and 2 type
Growth factors of the platelet-derived growth factor (PDCF) family have been thought to possess autocrine functions in certain neoplasms of mesenchymal and glial origin. This notion has been based on observations that these tumors express PDGF genes and produce PDGF-like growth factors. Correspondin
We have investigated the expression of platelet-derived endothelial-cell growth factorkhymidine phosphorylase (PD-ECGF/dThdPase) in human breast-cancer tissues by the immunocytochemical method using anti-PD-ECGF/ dThdPase monoclonal antibody. Out of I00 invasive-ductal-carcinoma tissue samples, 39 (
MBA-2, bone marrow-derived endothelial stromal cells, express platelet-derived growth factor (PDGF) A and B chain mRNAs and secrete PDCF activity that is induced by TGF-beta. Either chain of the PDGF molecule could modulate hematopoiesis and stromal cell growth. lntracellular pathways that regulate
## Abstract We have previously found that stimulation of normal neonatal fibroblasts with PDGF or EGF leads to a transient induction of PDGF A‐chain mRNA and the synthesis of PDGF‐AA proteins. This finding may imply the existence of an autocrine feedback mechanism to amplify the mitogenic signal un