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Expression of platelet-derived growth factor (PDGF) and PDGF receptor genes in the developing rat brain

โœ Scribed by Dr. U. R. Reddy; D. Pleasure

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
825 KB
Volume
31
Category
Article
ISSN
0360-4012

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โœฆ Synopsis

Steady-state levels of rat central nervous system (CNS) platelet-derived growth factor (PDGF) A-and B-chain mRNAs were measured by a polymerase chain reaction method employing a synthetic gene internal standard, and the rates of transcription of PDGF A-and B-chain genes in CNS were estimated by a nuclear runoff assay. The abundance of PDGF B-chain mRNA was an order of magnitude below that of PDGF A-chain mRNA, while the rate of PDGF B-chain transcription was only slightly below that for the PDGF A-chain gene, indicating that the half-life of PDGF B-chain in CNS is shorter than that of PDGF A-chain mRNA. No developmental alterations in expression of the PDGF A-and B-chain genes were detected. By contrast, Northern blots showed that steady-state levels of mRNAs encoding the two PDGF receptor proteins, a and p, were markedly higher in embryonic day 15 and postnatal day 6 rat brains than in later life. These results suggest that the actions of PDGF on the brain in vivo are regulated not at the level of PDGF A and B-chain gene expression, but rather by changes in the level of expression of PDGF a-and P-receptor genes.

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