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Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms

✍ Scribed by Magnus Ingelman-Sundberg


Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
275 KB
Volume
369
Category
Article
ISSN
0028-1298

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We previously clarified that major human drug metabolizing enzymes were expressed in a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mouse line established recently, in which the liver could be replaced by more than 80% with human hepatocytes. In the p