𝔖 Bobbio Scriptorium
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Approaches to deorphanization of human and microbial cytochrome P450 enzymes

✍ Scribed by F. Peter Guengerich; Zhongmei Tang; Qian Cheng; S. Giovanna Salamanca-Pinzón

Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
674 KB
Volume
1814
Category
Article
ISSN
1570-9639

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The metabolism of mirtazapine enantiomers was investigated in vitro using human lymphoblast microsomes transfected with human cDNA to overexpress either CYP1A2, CYP2C9, CYP2C19, CYP2D6 or CYP3A4 and assayed for mirtazapine enantiomers using a validated chiral method of high-performance liquid chroma