𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Contributions of human cytochrome P450 enzymes to glyburide metabolism

✍ Scribed by Lin Zhou; Suresh B. Naraharisetti; Li Liu; Honggang Wang; Yvonne S. Lin; Nina Isoherranen; Jashvant D. Unadkat; Mary F. Hebert; Qingcheng Mao


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
217 KB
Volume
31
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Characterization of human cytochrome P45
✍ Atsushi Kitamura; Yoshiko Mizuno; Kiyoshi Natsui; Masashi Yabuki; Setsuko Komuro πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 350 KB πŸ‘ 1 views

In vitro studies were carried out to identify the major contribution of CYP2C8, CYP2D6 and CYP3A4 to the metabolism of perospirone (cis-N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarboximide monohydrochloride dehydrate), a novel antipsychotic agent, using human liver mic

Expression and regulation of cytochrome
✍ Edward L. LeCluyse; Ajay Madan; Geraldine Hamilton; Kathy Carroll; Ryan DeHaan; πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 339 KB πŸ‘ 1 views

The aim of this study was to test suitable culture conditions for maintaining normal cellular cytoarchitecture and inducibility of P450 enzymes in primary cultures of human hepatocytes by prototypical inducers. The selectivity and sensitivity of a sandwich culture system were determined by treating

Rapid determination of enzyme activities
✍ Anima Ghosal; Neil Hapangama; Yuan Yuan; Xiaowen Lu; Debra Horne; James E. Patri πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 94 KB

## Abstract Cytochrome P450 (CYP) substrates that yield fluorescent metabolites were used for rapid screening of drug metabolism activities of 13 recombinant human cytochromes P450, human liver microsomes and human hepatocytes. Reproducible results were obtained using a fluorescent plate reader (Cy

Metabolism of thalidomide in human micro
✍ Steve K. Teo; P. J. Sabourin; K. O'Brien; K. A. Kook; S. D. Thomas πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 117 KB πŸ‘ 1 views

Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system (CYP). In this study, we examined the extent of thalidomide metabolism by preparations of pooled human microsomes, microsomes containing cloned human CYP isozymes (CYP1A2,

Induction of mouse cytochrome P450 2B en
✍ Lois D. Lehman-McKeeman; Sharon B. Stuard; Douglas Caudill; David R. Johnson πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 160 KB

Musk xylene (MX) is a synthetic nitromusk perfume ingredient that, although uniformly negative in genotoxicity testing, causes liver tumors in B6C3F1 mice. MX is also capable of inducing cytochrome P450 enzymes in a manner similar to that of phenobarbital (PB), which suggests that epigenetic mechani