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Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction

โœ Scribed by Laura Lowe Furge; F. Peter Guengerich

Publisher
The American Society for Biochemistry and Molecular Biology
Year
2006
Tongue
English
Weight
446 KB
Volume
34
Category
Article
ISSN
1470-8175

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In vitro studies were carried out to identify the major contribution of CYP2C8, CYP2D6 and CYP3A4 to the metabolism of perospirone (cis-N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarboximide monohydrochloride dehydrate), a novel antipsychotic agent, using human liver mic