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Human colony stimulating factor-1 receptor activates the C-raf-1 proto-oncogene kinase

✍ Scribed by Goutam Ghosh Choudhury; Victor L. Sylvia; Andrea Pfeifer; Ling-Mei Wang; Elizabeth Anne Smith; Alan Y. Sakaguchi


Book ID
117054930
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
638 KB
Volume
172
Category
Article
ISSN
0006-291X

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Colony stimulating factor-1 (CSF-1) is the primary regulator of the mononuclear phagocytic lineage acting through its transmembrane tyrosine kinase receptor, CSF-1R, that is the product of the c-fms proto-oncogene. Null mutations in either the ligand or the receptor genes result in a severe osteopet