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Host-mediated mutagenicity experiments with benzo[a]pyrene and two of its metabolites

✍ Scribed by Hansruedi Glatt; Michael Bücker; Karl L. Platt; Franz Oesch


Book ID
119092791
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
529 KB
Volume
156
Category
Article
ISSN
0165-1218

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## Abstract Individual metabolites of benzo (a)pyrene were isolated from rat liver microsomal incubation of the parent hydrocarbon, and subsequently bound to DNA in separate incubations with microsomes. Of the metabolites examined, by far the greatest binding resulted with 7,8‐dihydro‐7,8‐dihydroxy