PBPK model of benzo(a)pyrene and its 3-hydroxybenzo(a)pyrene metabolite in humans
✍ Scribed by Roberto Heredia Ortiz; Michele Bouchard
- Book ID
- 116925445
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 97 KB
- Volume
- 211
- Category
- Article
- ISSN
- 0378-4274
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract A study of the liver microsome‐mediated binding to added DNA of the phenol metabolites of benzo (a)‐pyrene (BP‐OH) and of 7,8‐dihydro‐7,8‐dihydroxybenzo (a)pyrene (BP‐7,8‐diol) suggested that as in the case of BP itself the reaction was catalysed by the enzyme aryl hydrocarbon hydroxyla
## Abstract The toxicokinetics of benzo(a)pyrene (BaP) and 3‐hydroxybenzo(a)pyrene (3‐OHBaP) were assessed in 36 male Sprague–Dawley rats injected intravenously with 40 µmol kg^1^ of BaP to explain the reported atypical urinary excretion profile of 3‐OHBaP. Blood, liver, kidney, lung, adipose tissu