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Excretion kinetics of urinary 3-hydroxybenzo[a]pyrene following dietary exposure to benzo[a]pyrene in humans

โœ Scribed by Yeh-Chung Chien; Chun-Ting Yeh

Book ID
118296805
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
423 KB
Volume
86
Category
Article
ISSN
0340-5761

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3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a