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Hormonal modulation of herpes simplex virus replication in a mouse neuroblastoma cell line

✍ Scribed by Gamil P. Sawiris; Dr. Robert J. Sydiskis; Nasir Bashirelahi

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
497 KB
Volume
8
Category
Article
ISSN
0887-8013

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✦ Synopsis

In this study, the effect of the synthetic glucocorticoid hormone dexamethasone (DXM) on HSV replication was studied in a DXM receptor-positive mouse neuroblastoma (NB) cell line. In cells treated with 10-7M DXM and then infected with HSV, there was a statistically significant 9-1 8-fold increase in the amount of virus produced in these cells compared to untreated controls. Adsorption kinetic studies with HSV were performed in DXM-treated NB cells and untreated controls. It was found that there was a significant increase in the adsorption rate of HSV in the DXM-treated cells as compared with the controls. During the course of these studies, a strain of NB cells was noted to have lost its ability to stimulate HSV replication

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