Homogeneously staining regions (HSR) in a human malignant melanoma
β Scribed by Sonia Brieux de Salum; Irma Slavutsky; Santiago Besuschio; Alberto Andino Pavlovsky
- Book ID
- 119102876
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 573 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0165-4608
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Cytogenetic studies on fresh human breast cancers revealed that homogeneously staining regions (HSRs), which are assumed t o represent DNA amplification, are observed in almost half of the cases. To search for a possible relationship between HSRs and proto-oncogene amplification, I 6 proto-oncogenes
## Abstract Direct chromosome analysis with Gβbanding revealed homogeneously staining regions (HSR) in five of 16 human solid malignant tumours of different histological types. The HSRs were localized either terminally or interstitially on the marker chromosomes. The great stability of the HSRβcarr