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Homogeneously staining regions on marker chromosomes in malignancy

✍ Scribed by Gy. Kovacs

Book ID
102278844
Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
302 KB
Volume
23
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Direct chromosome analysis with G‐banding revealed homogeneously staining regions (HSR) in five of 16 human solid malignant tumours of different histological types. The HSRs were localized either terminally or interstitially on the marker chromosomes. The great stability of the HSR‐carrying markers in the tumour cells suggests an interrelationship of malignant cell proliferation with the HSR. In a single case the HSR showed a moderate staining intensity for C‐heterochromatin.

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Characterization of recurrent homogeneou
Characterization of recurrent homogeneously staining regions in 72 breast carcinomas
✍ Jacqueline Bernardino; Françoise Apiou; Michèle Gerbault-Seureau; Bernard Malfoy 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 161 KB

Cytogenetic analyses were performed on 223 breast carcinomas, of which 60% contained homogeneously staining regions (hsr), an intrachromosomal cytogenetic feature of gene amplification. The precise hsr localization could be determined for 123 hsr from 72 cases. The juxtacentromeric region of chromos