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Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer’s disease

✍ Scribed by Sara Cervantes; Roser Gonzàlez-Duarte; Gemma Marfany


Book ID
117103319
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
346 KB
Volume
505
Category
Article
ISSN
0014-5793

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To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentration of amyloid beta-protein (A beta) ending at A beta 42(43) in vivo, we performed a blinded comparison