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Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors

✍ Scribed by James R Van Brocklyn; Babak Behbahani; Norman H Lee

Book ID
117772145
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
205 KB
Volume
1582
Category
Article
ISSN
1388-1981

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## Abstract G protein‐coupled receptors (GPCRs) for lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) transduce signals to many functions of normal cells. Most human cancer cells upregulate S1P and LPA GPCRs, in patterns distinctive for each type of tumor. The findings that 1‐alpha, 25‐