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Expression of Sphingosine 1-phosphate receptor S1p1/EDG-1 during rat limb development

✍ Scribed by T. Matsuoka; T. Makino; K. Noritake; K. Shimomura; A. Sanbuissho

Book ID
113875744
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
52 KB
Volume
30
Category
Article
ISSN
0890-6238

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## Abstract G protein‐coupled receptors (GPCRs) for lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) transduce signals to many functions of normal cells. Most human cancer cells upregulate S1P and LPA GPCRs, in patterns distinctive for each type of tumor. The findings that 1‐alpha, 25‐