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Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors

✍ Scribed by Michael J Kluk; Timothy Hla

Book ID: 117772143
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 127 KB
Volume: 1582
Category: Article
ISSN: 1388-1981
DOI: 10.1016/s1388-1981(02)00139-7

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## Abstract G protein‐coupled receptors (GPCRs) for lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) transduce signals to many functions of normal cells. Most human cancer cells upregulate S1P and LPA GPCRs, in patterns distinctive for each type of tumor. The findings that 1‐alpha, 25‐