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Signalling of sphingosine-1-phosphate in Müller glial cells via the S1P/EDG-family of G-protein-coupled receptors

✍ Scribed by Mirko Esche; Petra G. Hirrlinger; Katja Rillich; Yousef Yafai; Thomas Pannicke; Andreas Reichenbach; Michael Weick


Book ID
116772372
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
205 KB
Volume
480
Category
Article
ISSN
0304-3940

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## Abstract G protein‐coupled receptors (GPCRs) for lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) transduce signals to many functions of normal cells. Most human cancer cells upregulate S1P and LPA GPCRs, in patterns distinctive for each type of tumor. The findings that 1‐alpha, 25‐