Homoallylic rearrangement of 19-iodocholest-5-en-3β-ol: New adrenal scanning agent
✍ Scribed by M. Maeda; M. Kojima; H. Ogawa; K. Nitta; T. Ito
- Book ID
- 119481347
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 484 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0039-128X
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## Abstract 6β‐Iodomethyl‐19‐norcholest‐5(10)‐en‐3α‐ol (VI) was synthesized by the homoallylic rearrangement of 19‐iodocholest‐5‐en‐3α‐ol (V), which was obtained by the hydrolysis of 19‐iodocholest‐5‐en‐3α‐ol acetate derived from the displacement of cholest‐5‐ene‐3α,19‐diol 3‐acetate 19‐toluene‐p‐s
## Abstract A new adrenal cortex imaging agent. 6β‐^131^ I‐iodomethyl‐19‐norcholest‐5(10)‐en‐3β‐ol (NP‐59)[__I__] was synthesized by the homallylic rearrangement of 19‐iodocholesterol or directly from cholest‐5‐ene‐3β, 19‐diol‐19‐toluene‐p‐sulfonate via homoallylic rearrangement with the iodide ion