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Synthesis of iodine-131 labelled 6β-iodomethyl-19-norcholest-5(10)-en-3α-ol and 19-iodocholest-5-en-3α-ol

✍ Scribed by H. Komatsu,; M. Maeda; H. Morita; H. Shimoirisa; M. Kojima

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
357 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

6β‐Iodomethyl‐19‐norcholest‐5(10)‐en‐3α‐ol (VI) was synthesized by the homoallylic rearrangement of 19‐iodocholest‐5‐en‐3α‐ol (V), which was obtained by the hydrolysis of 19‐iodocholest‐5‐en‐3α‐ol acetate derived from the displacement of cholest‐5‐ene‐3α,19‐diol 3‐acetate 19‐toluene‐p‐sulfonate with sodium iodide in isopropanol.

The radioiodinated V and VI were prepared by isotope exchange with sodium iodide‐I‐131 in acetone.

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