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A simple and efficient synthesis of [3α-3H]5α-androst-16-en-3β-ol

✍ Scribed by S. Ren; D. Hesk; P. McNamara; D. Koharski

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
110 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

An efficient one step synthesis of [3__α__‐^3^H]5__α__‐androst‐16‐en‐3__β__‐ol by NaBT~4~ reduction of a ketone precursor is described. The specific activity of the product was 21.6 Ci/mmol with a radiochemical purity >99%. Synthesis of the precursor, 5__α__‐androst‐16‐en‐3‐one, from commercially available 5__α__‐androst‐16‐en‐3__α__‐ol is also presented. Copyright © 2006 John Wiley & Sons, Ltd.

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