P r e v i o u s l y , we had s u c e s s f u l l y s y n t h e s i z e d [ 5a. 6a-HIandrost-16-en-3-one (3) from 3B-acetoxy-androst-5-en-17-0ne (1) i n f i v e s t e p s 121. After c a t a l y t i c hydrogenation of t h e 5-double bond of (1) w i t h T2 t h e corresponding 17-tosylhydrazone had to
Synthese des tritiummarkierten eberpheromons [5α, 6α-3H]-5α-androst-16-en-3-on
✍ Scribed by H. Wagner; J. Römer
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 329 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
The synthesis of [5α, 6α‐^3^H]‐5α‐androst‐16‐en‐3‐one, starting with the catalytic tritiation of 3β‐acetoxy‐androst‐5‐en‐17‐one, is described. The so‐called “boar taint ketone” was obtained with high specific activity (21 Ci/mmol) and radiochemical purity better than 98 %.
📜 SIMILAR VOLUMES
## Abstract An efficient one step synthesis of [3__α__‐^3^H]5__α__‐androst‐16‐en‐3__β__‐ol by NaBT~4~ reduction of a ketone precursor is described. The specific activity of the product was 21.6 Ci/mmol with a radiochemical purity >99%. Synthesis of the precursor, 5__α__‐androst‐16‐en‐3‐one, from co
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Analysis of the olfactory responses of men and women to a pure sample of 5α‐androst‐16‐en‐3‐one showed that 7·6% of women were unable to detect the odour compared with 44·3% of men. For subjects able to detect the odour, there was a highly significant difference between sexes in the hed
## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy