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Regio-controlled synthesis of 4α-(3H3}methyl-5α-cholestan-3β-ol

✍ Scribed by I. Victor Ekhato; Cecil H. Robinson

Publisher: John Wiley and Sons
Year: 1986
Tongue: French
Weight: 243 KB
Volume: 23
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580230411

No coin nor oath required. For personal study only.

✦ Synopsis

4a-(3H )Methy1-5a-cholestan-38-01 was r e g i o s e l e c t i v e l y prepared from 5a-cho?est-I-en-3-one v i a a l k y l a t i o n with methyl i o d i d e , hydrogenation, and LAH reduction. The f i n a l and intermediate products were c h a r a c t e r i s e d by spectroscopic methods. Regio-control l e d synthesis, 4a-(3H3)Methy1-5a-cholestan-38-01, 5a-Cholest-1,3-dien-3-01 t r i m e t h y l s i l y l ether. D e m s o f t h i s synthesis a r e given.

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