𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of (25S)-5α-cholestane-3β, 26-DIOL[2,4,2′,4′-3H4]

✍ Scribed by Roberto Bovara; Renato Longhi; Francesco Nicotra; Giuseppe Vecchio

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
308 KB
Volume
13
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

(25S)–5α‐cholestane‐3β, 26‐diol [2,4,2′,4′–^3^H~4~] was synthesized by hydrogenation of neotigogenin acetate 2, followed by acetylation to (25S)‐5α‐furostane‐3β, 26‐diol diacetate 5; this was oxidized to (25S)–16–22‐dioxo‐5α‐cholestane‐3β, 26‐diol diacetate 6. Clemmensen reduction of the last product afforded (25S)–5α‐cholestane‐3β, 26‐diol 26‐monoacetate 9, which was oxidized to 3‐oxo‐derivative 12; this was tritium labelled by base‐catalyzed exchange with 0.1 N‐NaOH in iso PrO^3^H and reduced to 14 with NaBH~4~.

📜 SIMILAR VOLUMES

Regio-controlled synthesis of 4α-(3H3}me
Regio-controlled synthesis of 4α-(3H3}methyl-5α-cholestan-3β-ol
✍ I. Victor Ekhato; Cecil H. Robinson 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 French ⚖ 243 KB

4a-(3H )Methy1-5a-cholestan-38-01 was r e g i o s e l e c t i v e l y prepared from 5a-cho?est-I-en-3-one v i a a l k y l a t i o n with methyl i o d i d e , hydrogenation, and LAH reduction. The f i n a l and intermediate products were c h a r a c t e r i s e d by spectroscopic methods. Regio-contr

Synthesis and α-Mannosidase Inhibitory E
Synthesis and α-Mannosidase Inhibitory Evaluation of (2R,3R,4S)- and (2S,3R,4S)-2-(Aminomethyl)pyrrolidine-3,4-diol Derivatives
✍ Florence Popowycz; Sandrine Gerber-Lemaire; Eliazar Rodriguez-García; Catherine 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 485 KB 👁 1 views

The synthesis of 46 derivatives of (2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol is reported (Scheme 1 and Fig. 3), and their inhibitory activities toward a-mannosidases from jack bean (B) and almonds (A) are evaluated (Table ). The most-potent inhibitors are (2R,3R,4S)-2-{[([1,1'-biphenyl]-4-ylmet

Synthesis of 2,4-Dinitrochlorobenzene-3,
Synthesis of 2,4-Dinitrochlorobenzene-3,5-3H
✍ Ken-Ichi Kudo; Takayoshi Adachi; Michio Endo 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 French ⚖ 146 KB 👁 1 views

Coups/minute Acide L-a-aminoadipique 800 000 Acide chloracttyl-D-a-aminoadipique 9 200 000 30 -ACIDE D-a-AMINOADIPIQUE 14C-6. L'acide chloracttyl-D-a-aminoadipique est hydrolysC pendant 2 heures par de l'acide chlorhydrique 2 N a reflux. A p r b concentration, l'acide D-a-aminoadipique est purifik p