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hOGG1 Ser326CysPolymorphism and Breast Cancer Risk among Asian Women

✍ Scribed by Ji-Yeob Choi; Nobuyuki Hamajima; Kazuo Tajima; Keun-Young Yoo; Kyung-Sik Yoon; Sue Kyung Park; Sook-Un Kim; Kyung-Mu Lee; Dong-Young Noh; Se-Hyun Ahn; Kuk-Jin Choe; Wonshik Han; Ari Hirvonen; Daehee Kang


Book ID
110433941
Publisher
Springer US
Year
2003
Tongue
English
Weight
60 KB
Volume
79
Category
Article
ISSN
0167-6806

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Ser326Cys polymorphism in the hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in oxidatively damaged DNA, has been identified and the variant genotype appears to be related to susceptibility to certain cancers. We investigated the association between Ser326Cys polymorphism and squamo

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## Abstract Oxidative stress is involved in many types of DNA damage, __e.g.,__ resulting in 8‐hydroxyguanine adducts. Since a human counterpart exists for the yeast gene __OGG1__ (__hOGG1__) encoding an enzyme that repairs 8‐hydroxyguanine, its polymorphism, Ser^326^Cys, might have potential as a