The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis
โ Scribed by Weiguang Yuan; Lidan Xu; Yuanxi Feng; Yue Yang; Wangyang Chen; Jingwei Wang; Da Pang; Dianjun Li
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 207 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0167-6806
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Ser326Cys polymorphism in the hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in oxidatively damaged DNA, has been identified and the variant genotype appears to be related to susceptibility to certain cancers. We investigated the association between Ser326Cys polymorphism and squamo
## Abstract Oxidative stress is involved in many types of DNA damage, __e.g.,__ resulting in 8โhydroxyguanine adducts. Since a human counterpart exists for the yeast gene __OGG1__ (__hOGG1__) encoding an enzyme that repairs 8โhydroxyguanine, its polymorphism, Ser^326^Cys, might have potential as a
## Abstract The human oxoguanine glycosylase 1(hOGG1) gene encodes a DNA glycosylase that is involved in excision repair of 8โOHโdG (8โhydroxyโ2โdeoxyguanine) from oxidativelyโdamaged DNA. To determine whether hOGG1 plays a role in the risk for adenocarcinoma of the gallbladder, we tested the assoc