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The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis

โœ Scribed by Weiguang Yuan; Lidan Xu; Yuanxi Feng; Yue Yang; Wangyang Chen; Jingwei Wang; Da Pang; Dianjun Li


Publisher
Springer US
Year
2010
Tongue
English
Weight
207 KB
Volume
122
Category
Article
ISSN
0167-6806

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Ser326Cys polymorphism in the hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in oxidatively damaged DNA, has been identified and the variant genotype appears to be related to susceptibility to certain cancers. We investigated the association between Ser326Cys polymorphism and squamo

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## Abstract Oxidative stress is involved in many types of DNA damage, __e.g.,__ resulting in 8โ€hydroxyguanine adducts. Since a human counterpart exists for the yeast gene __OGG1__ (__hOGG1__) encoding an enzyme that repairs 8โ€hydroxyguanine, its polymorphism, Ser^326^Cys, might have potential as a

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