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HOGG1 Ser326Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese

✍ Scribed by Toshiro Takezaki; Chang-ming Gao; Jian-zhong Wu; Zhong-you Li; Jian-dong Wang; Jian-hua Ding; Yan-ting Liu; Xu Hu; Tian-liang Xu; Kazuo Tajima; Haruhiko Sugimura

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
70 KB
Volume
99
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Oxidative stress is involved in many types of DNA damage, e.g., resulting in 8‐hydroxyguanine adducts. Since a human counterpart exists for the yeast gene OGG1 (hOGG1) encoding an enzyme that repairs 8‐hydroxyguanine, its polymorphism, Ser^326^Cys, might have potential as a genetic marker for cancer susceptibility. To investigate its association with stomach cancer risk and possible interactions with environmental factors, we conducted a case‐control study of 101 stomach cancer cases and 198 controls using PCR‐single‐strand conformation polymorphism and a questionnaire approach. The proportional distribution of the Cys/Cys alleles did not differ between stomach cancer cases and controls, but subgroup analyses revealed that a frequent drinking habit elevated the odds ratio (OR) for stomach cancer in Cys/Cys compared to Ser/Ser and Ser/Cys carriers. The ORs with frequent consumption of pickled vegetables and meat tended to be higher in Cys/Cys than in Ser/Ser and Ser/Cys carriers, these interactions being on the borderline of statistical significance. Our findings suggest that the hOGG1 Ser^326^Cys polymorphism may alter the impact of some environmental factors on stomach cancer development. For confirmation, an additional study with a larger number of subjects is now required. © 2002 Wiley‐Liss, Inc.

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