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Highly Endo -Selective and Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylide with α-Enones Catalyzed by a Silver(I)/ThioClickFerrophos Complex

✍ Scribed by Oura, Ichiro; Shimizu, Kenta; Ogata, Kenichi; Fukuzawa, Shin-ichi


Book ID
120278611
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
183 KB
Volume
12
Category
Article
ISSN
1523-7060

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The first catalytic endo-selective 1,3-dipolar cycloaddition of azomethine ylides and vinyl phenyl sulfone has been developed successfully. The highly efficient silver acetate (AgOAc)/TF-Bi-phamPhos catalytic system exhibited high reactivity, excellent diastereoselectivity (> 98:2), good enantiosele